what is polyarteritis nodosa?Polyarteritis nodosa is an inflammation of blood vessels (vasculitis) rare but potentially fatal disease that damages the walls of the arteries of small and medium-sized body. This damage reduces blood supply and nutrients to the arteries, which causes the injury or destruction of surrounding tissue in many parts of the body. The disease most commonly affects the kidneys, the nerves of the arms and legs and abdominal organs, but can also affect the skin, joints, brain, heart, eyes and genitals.

In individual organs, polyarteritis nodosa can have the following effects:

- Kidneys: renal failure and high blood pressure associated with kidney failure
- Nervous system: nerve damage in the arms and legs, loss of sensation and movement caused by a specific lesion of a nerve. In the brain, the injury can trigger strokes, seizures or sudden disturbances in nerve function.
- Abdominal organs: intestinal pain, liver or pancreas, especially after eating, or even death of a portion of an organ caused by interruption of blood supply. May break suddenly artery aneurysms, which are inflammation (swelling) like a balloon that formed along an artery in the areas where the vasculitis has weakened the arterial wall. This can lead to hemorrhage (bleeding) death in the abdomen, accompanied by severe abdominal pain.
- Heart: heart attack as well as inflammation of the lining of the heart (pericarditis). Congestive heart failure can make breathing difficult, as the fluid builds up behind the heart and into the lungs.
- Skin: rashes, skin nodules and purple, caused by bleeding from damaged capillaries.
It is unknown exactly why many people have this disease because the symptoms can be confused with other forms of vasculitis. A study in Britain showed that polyarteritis nodosa occurs in three or four out of every million people each year in the UK. In the U.S., may occur more often. According to a study conducted in Minnesota, occurs in up to nine out of every 1 million people.

Polyarteritis nodosa can affect people of any race and age, but most commonly affects adults between 40 and 50 years, and also attacks two times more men than women.

Although no known cause of polyarteritis nodosa, some research has been linked to the presence of microscopic groups of antibodies the body’s defense system, foreign proteins as well as portions of a virus. In some people with polyarteritis nodosa, the disease appears to be triggered by a viral liver infection, either hepatitis B or C.

In some patients, researchers have demonstrated at least one autoantibody (an autoimmune protein attacks the body instead of a foreign invader) which seems to be related to arterial damage of polyarteritis nodosa. This autoantibody, called neutrophil Cytoplasmic Antibody was also detected in the blood of patients with other vasculitic disorders. However, most patients with polyarteritis nodosa do not have this antibody in their blood or tissues, and many experts do not believe that this antibody has an important role in this disease.

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3 Responses to “What is Polyarteritis nodosa?”

  • Marcene Dalin:

    Go to the nearest hospital emergency room!!!!!!!!!!!! You have no idea how bad this could get.

  • vasculitis disease:

    To Thomas. Of course they do not tell you every single side effect of the vaccine but it is available for you IF YOU ASK. The fact that you even brought that up shows you do not care anyways so why is it such a problem for you? When you buy a car they salesman does not read you the 300 page manual, you do it for yourself. Stop being ignorant and lazy and actually go do some research. Do you even know who wrote this article and whether he is a licensed physician or just some idiot trying overreacting and trying to scare you? Why don’t you go to a reliable source like the FDA, or the CDC rather than clicking the first option that comes up on google. There is no point in calling someone an idiot, if you deny facts, an actual physician, have not done any personal research, and are ovbiously very gullible, because you are just being a hypocrit.

  • Rosemary Kaighn:

    I think it should be a choice to have the shots or not but when you work in the health care industry this should be mandatory(if not shots then blood work testing) as you are dealing with many different people whether it be the elderly or what have you. But this could also be argued with wearing the face masks n hand sanitizing. In Canada most of the hospitals I’ve been in all the nurses wear the face masks and wash hands/sanitize hands constantly.Think about your future. What would you like or who would you want to be around at that time. Someone who could have the flu not realizing it, passing it on to you and you dying because you’re system can not handle it. There are people who are just carriers of these diseases, they do not actually become affected by the disease. Now I’m not for the vaccine’s either as they do put things into your body that shouldn’t be there, and with everything going on in this day and age how can you be sure that is what you are getting? It’s hard to choose but its a choice you do have to make. I wish all of you health care workers luck with the mandating vaccines. I think it goes against human rights and this is just so wrong….Just another way of taking control of more lives.

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